Research Groups

 

Publications of Alexander Heckel (Results: 69)

 

Activity-dependent spatially localized miRNA maturation in neuronal dendrites.
Science (New York, N.Y.)
Sambandan S, Akbalik G, Kochen L, Rinne J, Kahlstatt J, Glock C, Tushev G, Alvarez-Castelao B, Heckel A, Schuman EM PubMed
Feb 2017 Volume: 355 Issue: 6325 Pages: 634-637

Photo-Tethers for the (Multi-)Cyclic, Conformational Caging of Long Oligonucleotides.
Angewandte Chemie (International ed. in English)
Seyfried P, Eiden L, Grebenovsky N, Mayer G, Heckel A PubMed
Jan 2017 Volume: 56 Issue: 1 Pages: 359-363

Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging.
Angewandte Chemie (International ed. in English)
Fichte MA, Weyel XM, Junek S, Schäfer F, Herbivo C, Goeldner M, Specht A, Wachtveitl J, Heckel A PubMed
Jul 2016 Volume: 55 Issue: 31 Pages: 8948-52

Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
Angewandte Chemie (International ed. in English)
Thevarpadam J, Bessi I, Binas O, Gonçalves DP, Slavov C, Jonker HR, Richter C, Wachtveitl J, Schwalbe H, Heckel A PubMed
Feb 2016 Volume: 55 Issue: 8 Pages: 2738-42

Sensitive detection of cancer cells using light-mediated apta-PCR.
Methods (San Diego, Calif.)
Civit L, Pinto A, Rodrigues-Correia A, Heckel A, O'Sullivan CK, Mayer G PubMed
Mar 2016 Volume: 97 Issue: Pages: 104-9

Azobenzene C-Nucleosides for Photocontrolled Hybridization of DNA at Room Temperature.
Chemistry (Weinheim an der Bergstrasse, Germany)
Goldau T, Murayama K, Brieke C, Asanuma H, Heckel A PubMed
Dec 2015 Volume: 21 Issue: 49 Pages: 17870-6

Caged Fluoride: Photochemistry and Applications of 4-Hydroxyphenacyl Fluoride.
Organic letters
Slanina T, Šebej P, Heckel A, Givens RS, Klán P PubMed
Oct 2015 Volume: 17 Issue: 19 Pages: 4814-7

Ultrafast Spectroscopy of Hydroxy-Substituted Azobenzenes in Water.
Chemistry (Weinheim an der Bergstrasse, Germany)
Steinwand S, Halbritter T, Rastädter D, Ortiz-Sánchez JM, Burghardt I, Heckel A, Wachtveitl J PubMed
Oct 2015 Volume: 21 Issue: 44 Pages: 15720-31

A two-photon activatable amino acid linker for the induction of fluorescence.
Chemical communications (Cambridge, England)
Friedrich F, Klehs K, Fichte MA, Junek S, Heilemann M, Heckel A PubMed
Oct 2015 Volume: 51 Issue: 84 Pages: 15382-5

In Search of an Efficient Photoswitch for Functional RNA: Design Principles from a Microscopic Analysis of Azobenzene-linker-RNA Dynamics with Different Linkers.
The journal of physical chemistry. B
Mondal P, Biswas M, Goldau T, Heckel A, Burghardt I PubMed
Aug 2015 Volume: 119 Issue: 34 Pages: 11275-86

Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications.
Organic letters
Özçoban C, Halbritter T, Steinwand S, Herzig LM, Kohl-Landgraf J, Askari N, Groher F, Fürtig B, Richter C, Schwalbe H, Suess B, Wachtveitl J, Heckel A PubMed
Mar 2015 Volume: 17 Issue: 6 Pages: 1517-20

Characterization of conformational dynamics of bistable RNA by equilibrium and non-equilibrium NMR.
Current protocols in nucleic acid chemistry
Fürtig B, Reining A, Sochor F, Oberhauser EM, Heckel A, Schwalbe H PubMed
Dec 2014 Volume: 55 Issue: Pages: 11.13.1-16

Click chemistry facilitates direct labelling and super-resolution imaging of nucleic acids and proteins†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4ra01027bClick here for additional data file.
RSC advances
Raulf A, Spahn CK, Zessin PJ, Finan K, Bernhardt S, Heckel A, Heilemann M PubMed
Jul 2014 Volume: 4 Issue: 57 Pages: 30462-30466

Reversible photoswitching of RNA hybridization at room temperature with an azobenzene C-nucleoside.
Chemistry (Weinheim an der Bergstrasse, Germany)
Goldau T, Murayama K, Brieke C, Steinwand S, Mondal P, Biswas M, Burghardt I, Wachtveitl J, Asanuma H, Heckel A PubMed
Feb 2015 Volume: 21 Issue: 7 Pages: 2845-54

Direct observation of mobility state transitions in RNA trajectories by sensitive single molecule feedback tracking.
Nucleic acids research
Spille JH, Kaminski TP, Scherer K, Rinne JS, Heckel A, Kubitscheck U PubMed
Jan 2015 Volume: 43 Issue: 2 Pages: e14

Selective uncaging of DNA through reaction rate selectivity.
Organic letters
Rodrigues-Correia A, Knapp-Bühle D, Engels JW, Heckel A PubMed
Oct 2014 Volume: 16 Issue: 19 Pages: 5128-31

Wavelength-selective uncaging of oligonucleotides.
Current protocols in nucleic acid chemistry
Rodrigues-Correia A, Seyfried P, Heckel A PubMed
Jun 2014 Volume: 57 Issue: Pages: 6.11.1-32

Three-dimensional protein networks assembled by two-photon activation.
Angewandte Chemie (International ed. in English)
Gatterdam V, Ramadass R, Stoess T, Fichte MA, Wachtveitl J, Heckel A, Tampé R PubMed
May 2014 Volume: 53 Issue: 22 Pages: 5680-4

Influence of the absolute configuration of npe-caged cytosine on DNA single base pair stability.
Angewandte Chemie (International ed. in English)
Steinert HS, Schäfer F, Jonker HR, Heckel A, Schwalbe H PubMed
Jan 2014 Volume: 53 Issue: 4 Pages: 1072-5

Regulating angiogenesis with light-inducible AntimiRs.
Angewandte Chemie (International ed. in English)
Schäfer F, Wagner J, Knau A, Dimmeler S, Heckel A PubMed
Dec 2013 Volume: 52 Issue: 51 Pages: 13558-61

Aptamer-guided caging for selective masking of protein domains.
Angewandte Chemie (International ed. in English)
Rohrbach F, Schäfer F, Fichte MA, Pfeiffer F, Müller J, Pötzsch B, Heckel A, Mayer G PubMed
Nov 2013 Volume: 52 Issue: 45 Pages: 11912-5

Spiropyran photoswitches in the context of DNA: synthesis and photochromic properties.
Chemistry (Weinheim an der Bergstrasse, Germany)
Brieke C, Heckel A PubMed
Nov 2013 Volume: 19 Issue: 46 Pages: 15726-34

Four levels of wavelength-selective uncaging for oligonucleotides.
Organic letters
Rodrigues-Correia A, Weyel XM, Heckel A PubMed
Nov 2013 Volume: 15 Issue: 21 Pages: 5500-3

Light-inducible molecular beacons for spatio-temporally highly defined activation.
Chemical communications (Cambridge, England)
Rinne JS, Kaminski TP, Kubitscheck U, Heckel A PubMed
Jun 2013 Volume: 49 Issue: 47 Pages: 5375-7

Light-controlled tools.
Angewandte Chemie (International ed. in English)
Brieke C, Rohrbach F, Gottschalk A, Mayer G, Heckel A PubMed
Aug 2012 Volume: 51 Issue: 34 Pages: 8446-76

Ultrafast dynamics of a spiropyran in water.
Journal of the American Chemical Society
Kohl-Landgraf J, Braun M, Özçoban C, Gonçalves DP, Heckel A, Wachtveitl J PubMed
Aug 2012 Volume: 134 Issue: 34 Pages: 14070-7

Computational design of improved two-photon active caging compounds based on nitrodibenzofuran.
Journal of computational chemistry
Dreuw A, Polkehn MA, Binder R, Heckel A, Knippenberg S PubMed
Aug 2012 Volume: 33 Issue: 22 Pages: 1797-805

Caged glutathione - triggering protein interaction by light.
Angewandte Chemie (International ed. in English)
Gatterdam V, Stoess T, Menge C, Heckel A, Tampé R PubMed
Apr 2012 Volume: 51 Issue: 16 Pages: 3960-3

Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs.
RNA (New York, N.Y.)
Wurm JP, Griese M, Bahr U, Held M, Heckel A, Karas M, Soppa J, Wöhnert J PubMed
Mar 2012 Volume: 18 Issue: 3 Pages: 412-20

Light-activatable molecular beacons with a caged loop sequence.
Chemical communications (Cambridge, England)
Joshi KB, Vlachos A, Mikat V, Deller T, Heckel A PubMed
Mar 2012 Volume: 48 Issue: 22 Pages: 2746-8

Functional detection of proteins by caged aptamers.
ACS chemical biology
Pinto A, Lennarz S, Rodrigues-Correia A, Heckel A, O'Sullivan CK, Mayer G PubMed
Feb 2012 Volume: 7 Issue: 2 Pages: 360-6

Caged glucosamine-6-phosphate for the light-control of riboswitch activity.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Wulffen B, Buff MC, Pofahl M, Mayer G, Heckel A PubMed
Mar 2012 Volume: 11 Issue: 3 Pages: 489-92

Coumarin-caged dG for improved wavelength-selective uncaging of DNA.
Organic letters
Menge C, Heckel A PubMed
Sep 2011 Volume: 13 Issue: 17 Pages: 4620-3

A light trigger for DNA nanotechnology.
Small (Weinheim an der Bergstrasse, Germany)
Schmidt TL, Koeppel MB, Thevarpadam J, Gonçalves DP, Heckel A PubMed
Aug 2011 Volume: 7 Issue: 15 Pages: 2163-7

Photon cascade with clip-on fluorophores.
Chemphyschem : a European journal of chemical physics and physical chemistry
Friedrich F, Heckel A PubMed
Aug 2011 Volume: 12 Issue: 11 Pages: 2073-5

Construction of a structurally defined double-stranded DNA catenane.
Nano letters
Schmidt TL, Heckel A PubMed
Apr 2011 Volume: 11 Issue: 4 Pages: 1739-42

Wavelength-selective uncaging of dA and dC residues.
Organic letters
Schäfer F, Joshi KB, Fichte MA, Mack T, Wachtveitl J, Heckel A PubMed
Mar 2011 Volume: 13 Issue: 6 Pages: 1450-3

The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA.
Nucleic acids research
Meyer B, Wurm JP, Kötter P, Leisegang MS, Schilling V, Buchhaupt M, Held M, Bahr U, Karas M, Heckel A, Bohnsack MT, Wöhnert J, Entian KD PubMed
Mar 2011 Volume: 39 Issue: 4 Pages: 1526-37

Comparison of the duplex-destabilizing effects of nucleobase-caged oligonucleotides.
Analytical and bioanalytical chemistry
Rodrigues-Correia A, Koeppel MB, Schäfer F, Joshi KB, Mack T, Heckel A PubMed
Jan 2011 Volume: 399 Issue: 1 Pages: 441-7

DNA minicircles connected via G-quadruplex interaction modules.
Small (Weinheim an der Bergstrasse, Germany)
Gonçalves DP, Schmidt TL, Koeppel MB, Heckel A PubMed
Jun 2010 Volume: 6 Issue: 12 Pages: 1347-52

Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates.
Chemical communications (Cambridge, England)
Ackermann D, Rasched G, Verma S, Schmidt TL, Heckel A, Famulok M PubMed
Jun 2010 Volume: 46 Issue: 23 Pages: 4154-6

Prion protein amyloid formation involves structural rearrangements in the C-terminal domain.
Chembiochem : a European journal of chemical biology
Kumar J, Sreeramulu S, Schmidt TL, Richter C, Vonck J, Heckel A, Glaubitz C, Schwalbe H PubMed
Jun 2010 Volume: 11 Issue: 9 Pages: 1208-13

A double-stranded DNA rotaxane.
Nature nanotechnology
Ackermann D, Schmidt TL, Hannam JS, Purohit CS, Heckel A, Famulok M PubMed
Jun 2010 Volume: 5 Issue: 6 Pages: 436-42

The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase.
Nucleic acids research
Wurm JP, Meyer B, Bahr U, Held M, Frolow O, Kötter P, Engels JW, Heckel A, Karas M, Entian KD, Wöhnert J PubMed
Apr 2010 Volume: 38 Issue: 7 Pages: 2387-98

Dependence of aptamer activity on opposed terminal extensions: improvement of light-regulation efficiency.
Nucleic acids research
Buff MC, Schäfer F, Wulffen B, Müller J, Pötzsch B, Heckel A, Mayer G PubMed
Apr 2010 Volume: 38 Issue: 6 Pages: 2111-8

From selection to caged aptamers: identification of light-dependent ssDNA aptamers targeting cytohesin.
Bioorganic & medicinal chemistry letters
Mayer G, Lohberger A, Butzen S, Pofahl M, Blind M, Heckel A PubMed
Dec 2009 Volume: 19 Issue: 23 Pages: 6561-4

Probing the limits of liquid droplet laser desorption mass spectrometry in the analysis of oligonucleotides and nucleic acids.
Rapid communications in mass spectrometry : RCM
Hoffmann J, Schmidt TL, Heckel A, Brutschy B PubMed
Jul 2009 Volume: 23 Issue: 14 Pages: 2176-80

Pyrrole/imidazole-polyamide anchors for DNA tertiary interactions.
Small (Weinheim an der Bergstrasse, Germany)
Schmidt TL, Heckel A PubMed
Jul 2009 Volume: 5 Issue: 13 Pages: 1517-20

Structure-activity relationships of a caged thrombin binding DNA aptamer: insight gained from molecular dynamics simulation studies.
Journal of structural biology
Jayapal P, Mayer G, Heckel A, Wennmohs F PubMed
Jun 2009 Volume: 166 Issue: 3 Pages: 241-50

Differential regulation of protein subdomain activity with caged bivalent ligands.
Chembiochem : a European journal of chemical biology
Mayer G, Müller J, Mack T, Freitag DF, Höver T, Pötzsch B, Heckel A PubMed
Mar 2009 Volume: 10 Issue: 4 Pages: 654-7

Completion of a Programmable DNA-Binding Small Molecule Library.
Tetrahedron
Hsu CF, Phillips JW, Trauger JW, Farkas ME, Belitsky JM, Heckel A, Olenyuk BZ, Puckett JW, Wang CC, Dervan PB PubMed
Jul 2007 Volume: 63 Issue: 27 Pages: 6146-6151

Nucleobase-caged phosphoramidites for oligonucleotide synthesis.
Current protocols in nucleic acid chemistry
Heckel A PubMed
Jun 2007 Volume: Chapter 1 Issue: Pages: Unit 1.17

Building objects from nucleic acids for a nanometer world.
Biochimie
Heckel A, Famulok M PubMed
Jul 2008 Volume: 90 Issue: 7 Pages: 1096-107

Binding of hairpin polyamides to DNA studied by fluorescence correlation spectroscopy for DNA nanoarchitectures.
Analytical and bioanalytical chemistry
Nandi CK, Parui PP, Schmidt TL, Heckel A, Brutschy B PubMed
Mar 2008 Volume: 390 Issue: 6 Pages: 1595-603

DNA minicircles with gaps for versatile functionalization.
Angewandte Chemie (International ed. in English)
Rasched G, Ackermann D, Schmidt TL, Broekmann P, Heckel A, Famulok M PubMed
2008 Volume: 47 Issue: 5 Pages: 967-70

Light-dependent RNA interference with nucleobase-caged siRNAs.
RNA (New York, N.Y.)
Mikat V, Heckel A PubMed
Dec 2007 Volume: 13 Issue: 12 Pages: 2341-7

Polyamide struts for DNA architectures.
Angewandte Chemie (International ed. in English)
Schmidt TL, Nandi CK, Rasched G, Parui PP, Brutschy B, Famulok M, Heckel A PubMed
2007 Volume: 46 Issue: 23 Pages: 4382-4

Light-stimulated patterning of cells.
Chembiochem : a European journal of chemical biology
Mayer G, Heckel A PubMed
May 2007 Volume: 8 Issue: 8 Pages: 857-8

An anticoagulant with light-triggered antidote activity.
Angewandte Chemie (International ed. in English)
Heckel A, Buff MC, Raddatz MS, Müller J, Pötzsch B, Mayer G PubMed
Oct 2006 Volume: 45 Issue: 40 Pages: 6748-50

Biologically active molecules with a "light switch".
Angewandte Chemie (International ed. in English)
Mayer G, Heckel A PubMed
Jul 2006 Volume: 45 Issue: 30 Pages: 4900-21

Light-induced formation of G-quadruplex DNA secondary structures.
Chembiochem : a European journal of chemical biology
Mayer G, Kröck L, Mikat V, Engeser M, Heckel A PubMed
Nov 2005 Volume: 6 Issue: 11 Pages: 1966-70

A ribozyme for the aldol reaction.
Chemistry & biology
Fusz S, Eisenführ A, Srivatsan SG, Heckel A, Famulok M PubMed
Aug 2005 Volume: 12 Issue: 8 Pages: 941-50

Light regulation of aptamer activity: an anti-thrombin aptamer with caged thymidine nucleobases.
Journal of the American Chemical Society
Heckel A, Mayer G PubMed
Jan 2005 Volume: 127 Issue: 3 Pages: 822-3

Photoinduced transcription by using temporarily mismatched caged oligonucleotides.
Angewandte Chemie (International ed. in English)
Kröck L, Heckel A PubMed
Jan 2005 Volume: 44 Issue: 3 Pages: 471-3

A new DNA analogue with expanded size and scope.
Chembiochem : a European journal of chemical biology
Heckel A PubMed
Jun 2004 Volume: 5 Issue: 6 Pages: 765-7

Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates.
Nucleic acids research
Edelson BS, Best TP, Olenyuk B, Nickols NG, Doss RM, Foister S, Heckel A, Dervan PB PubMed
2004 Volume: 32 Issue: 9 Pages: 2802-18

U-pin polyamide motif for recognition of the DNA minor groove.
Chemistry (Weinheim an der Bergstrasse, Germany)
Heckel A, Dervan PB PubMed
Jul 2003 Volume: 9 Issue: 14 Pages: 3353-66

Preparation and characterization of TADDOLs immobilized on hydrophobic controlled-pore-glass silica gel and their use in enantioselective heterogeneous catalysis.
Chemistry (Weinheim an der Bergstrasse, Germany)
Heckel A, Seebach D PubMed
Feb 2002 Volume: 8 Issue: 3 Pages: 559-72

TADDOLs, Their Derivatives, and TADDOL Analogues: Versatile Chiral Auxiliaries.
Angewandte Chemie (International ed. in English)
Seebach D, Beck AK, Heckel A PubMed
Jan 2001 Volume: 40 Issue: 1 Pages: 92-138