Research Groups

 

Molecular Signaling

Our group study signaling pathways that control cell growth and differentiation and the reasons why they are deregulated in diseases such as cancer. We are interested in signaling by growth factor activated receptors and mechanisms underlying their endocytosis and degradation through actions of the scaffold protein CIN85 and the ubiquitin ligase Cbl. Our recent scientific interests are focused on the understanding how the ubiquitin pathways regulate cellular processes, such as receptor-mediated endocytosis, immune responses, DNA repair, proteasomal degradation and more recently on molecular basis of selective autophagy.

We utilize molecular biology, cell biology and biochemistry as well as genetically altered mice and cells derived from such animals to understand how molecular signals regulate cell functions in vivo. Advanced light microscopy is currently used to develop different sensors to monitor the specificity and length of ubiquitin chains in vivo.

Research Acker Palmer

Prof. Dr. Ivan Dikic
Buchmann Institute for
Molecular Life Sciences

Max-von-Laue-Str. 15
60438 Frankfurt am Main
Germany

Tel +49 (0)69 6301-42582
Fax +49 (0)69 6301-5577
Email: ivan.dikic(at)biochem2.de