Research Groups


Members of the Protein Reaction Control Group

Prof. Dr. Martin Grininger
Lichtenberg (W1)-Professor of the Volkswagen Foundation &
Group Leader
Vice Director BMLS


Professor & Group Leader
Phone: +49 (0)69 798-42705
grininger(at)chemie.uni-frankfurt.de
Website

Martin was a project leader in the group of Prof. Dieter Oesterhelt at the Max Planck Institute of Biochemistry, Martinsried before he moved to Goethe University Frankfurt in 2012 as Lichtenberg Professor of the Volkswagen Foundation.

   
Curriculum Vitae  
   
since June 2015 Vice-Director Buchmann Institute for Molecular Life Sciences (BMLS)
(Buchmann Institut für die molekularen Lebesnwissenschaften, Frankfurt am Main, Germany)
since 2012 Lichtenberg-Professor, Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes", Goethe University Frankfurt
2010-2011 Guest Professor, University of Vienna, Faculty of Chemistry, Austria
2006-2011 Group Leader of project group "Biological Chemistry", Max-Planck-Institute of Biochemistry, Martinsried near Munich, Germany
2002-2006 PhD, Ludwig Maximilians University Munich, Germany
2001-2002 Diploma in Chemistry, Technical University Graz, Austria
   
Awards and Fellowships  
   
2014 Preis für Exzellente Lehre am Fachbereich Biochemie, Chemie und Pharmazie der Goethe Universität Frankfurt
2007 Max-Planck-Institute of Biochemistry Junior Research Award
2001 Leonardo da Vinci Fellowship
   
 
Publications
 
Directed manipulation of a flavoprotein photocycle. Staudt, H; Hoesl, MG; Dreuw, A; Serdjukow, S; Oesterhelt, D; Budisa, N; Wachtveitl, J; Grininger, M; Angew Chem Int Ed Engl, 2013 Aug PubMed

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex. Ciccarelli, L; Connell, SR; Enderle, M; Mills, DJ; Vonck, J; Grininger, M; Structure, 2013 Jul PubMed

The flavoprotein dodecin as a redox probe for electron transfer through DNA. Yu, Y; Heidel, B; Parapugna, TL; Wenderhold-Reeb, S; Song, B; Schönherr, H; Grininger, M; Nöll, G; Angew Chem Int Ed Engl, 2013 Apr PubMed

Ultrafast excited-state deactivation of flavins bound to dodecin. Staudt, H; Oesterhelt, D; Grininger, M; Wachtveitl, J; J Biol Chem, 2012 May PubMed

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase. Anselmi, C; Grininger, M; Gipson, P; Faraldo-Gómez, JD; J Am Chem Soc, 2010 Sep PubMed

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase. Wende, A; Johansson, P; Vollrath, R; Dyall-Smith, M; Oesterhelt, D; Grininger, M; J Mol Biol, 2010 Jul PubMed

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy. Gipson, P; Mills, DJ; Wouts, R; Grininger, M; Vonck, J; Kühlbrandt, W; Proc Natl Acad Sci U S A, 2010 May PubMed

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase. Johansson, P; Mulinacci, B; Koestler, C; Vollrath, R; Oesterhelt, D; Grininger, M; Structure, 2009 Aug PubMed

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin. Nöll, G; Trawöger, S; von Sanden-Flohe, M; Dick, B; Grininger, M; Chembiochem, 2009 Mar PubMed

Dodecin is the key player in flavin homeostasis of archaea. Grininger, M; Staudt, H; Johansson, P; Wachtveitl, J; Oesterhelt, D; J Biol Chem, 2009 May PubMed

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers. Grininger, M; Nöll, G; Trawöger, S; Sinner, EK; Oesterhelt, D; Biointerphases, 2008 Sep PubMed

Inhibition of the fungal fatty acid synthase type I multienzyme complex. Johansson, P; Wiltschi, B; Kumari, P; Kessler, B; Vonrhein, C; Vonck, J; Oesterhelt, D; Grininger, M; Proc Natl Acad Sci U S A, 2008 Sep PubMed

Dodecin sequesters FAD in closed conformation from the aqueous solution. Grininger, M; Seiler, F; Zeth, K; Oesterhelt, D; J Mol Biol, 2006 Dec PubMed

Dodecins: a family of lumichrome binding proteins. Grininger, M; Zeth, K; Oesterhelt, D; J Mol Biol, 2006 Mar PubMed

Parameters affecting the X-ray dose absorbed by macromolecular crystals. Murray, JW; Rudiño-Piñera, E; Owen, RL; Grininger, M; Ravelli, RB; Garman, EF; J Synchrotron Radiat, 2005 May PubMed

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm. Grininger, M; Ravelli, RB; Heider, U; Zeth, K; Acta Crystallogr D Biol Crystallogr, 2004 Aug PubMed

Nataliya Kasanzeva

Administrative Assistant
Phone: +49 (0)69 798-46466
kasanzeva(at)em.uni.frankfurt.de

Nataliya helps us in administration and organization of the group.



Ilka Siebels

Technical Assistant
Phone: +49 (0)69 798-42533
siebels(at)chemie.uni-frankfurt.de

Dr. Karthik S. Paithankar

Postdoctoral Fellow
Phone: +49 (0)69 798-42533
karthik.paithankar(at)chemie.uni-frankfurt.de

Dr.rer.nat from University of Leipzig. After a post-doc in the Garman group at the University of Oxford, he was a beamline scientist at BESSY II synchrotron at Helmholtz-Zentrum Berlin.
His favorite pastime is coding and learning natural languages.

Dr. Peter Tufar

Postdoctoral Fellow
Phone: +49 (0)69 798-42533


After obtaining his graduate degree in Chemistry in the group of Prof. Mohamed A. Marahiel, Peter moved on to the Goethe University for his doctoral work in Biochemistry with Prof. Volker Dötsch. After a two-year postdoc with Prof. Mike D. Burkart at the University of California, San Diego, he returned to Frankfurt to continue his work on nonribosomal peptide synthetases.

Alexander Rittner

PhD Student
Phone: +49 (0)69 798-42533
rittner(at)chemie.uni-frankfurt.de

After studying biomedical chemistry until the "Vordiplom" in Mainz, Alex moved to Munich and did his bachelor's and master's degree in biochemistry at the Ludwig Maximilian University. His master's thesis was written in Zurich with Prof. Plückthun on G-protein coupled receptors. Alex joined the lab as a PhD student to work on the mammalian FAS, particularly on the human FAS.

Manuel Fischer

PhD Student
Phone: +49 (0)69 798-42533
ma.fischer(at)chemie.uni-frankfurt.de

Manuel studied chemistry at the Goethe University of Frankfurt focused on organic synthesis. In his PhD thesis, Manuel evaluates new strategies for the inhibition of fatty acid synthases.



Christina Heil

PhD Student
Phone: +49 (0)69 798-42533
csheil(at)stud.uni-frankfurt.de

Christina studied chemistry at the Goethe-University Frankfurt with a focus on chemical biology. During her master, she
performed structural studies on proteins at University of Tromsø. Her doctoral thesis involves conformational studies of
multi-functional proteins.

Florian Bourdeaux

PhD Student
Phone: +49 (0)69 798-42533
bourdeaux(at)chemie.uni-frankfurt.de

Florian studied chemistry at the Goethe-University Frankfurt. During his bachelor, he focused on analytic and surface chemistry. Through his master, he switched to biochemistry and did a master thesis on Mycobacterium tuberculosis Dodecin. In his PhD, Florian is working on functional studies of large proteins.

Maja Klaus

PhD Student
Phone: +49 (0)69 798-42533
mklaus(at)stud.uni-frankfurt.de

Maja studied Life Science at the Leibniz University Hannover with a focus on molecular biology and chemistry of natural products with
a master's thesis from Stanford. In summer 2015, Maja joined the lab as a PhD student.